Inhaled mannitol as a new mucolytic for treatment of cystic fibrosis
نویسندگان
چکیده
منابع مشابه
Optimising inhaled mannitol for cystic fibrosis in an adult population
ABSTRACT There has been remarkable progress in the treatment of cystic fibrosis (CF) patients over the past 20 years. However, limitations of standard therapies have highlighted the need for a convenient alternative treatment to effectively target the pathophysiologic basis of CF-related disease by improving mucociliary clearance of airway secretions and consequently improve lung function and r...
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Cystic Fibrosis is an autosomal recessive inheritable condition principally involving the lungs, pancreas, liver and intestines. Pulmonary involvement is characterized by airway inflammation and infection starting at an early age and is the primary cause of premature death. This paper will review the current situation in terms of prevalence of bacterial pathogens causing pulmonary infections an...
متن کاملThe effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study.
It has been postulated that hypertonic saline (HS) might impair the antimicrobial effects of defensins within the airways. Alternative non-ionic osmotic agents such as mannitol may thus be preferable to HS in promoting bronchial mucus clearance (BMC) in patients with cystic fibrosis (CF). This study reports the effect of inhalation of another osmotic agent, dry powder Mannitol (300 mg), compare...
متن کاملA pilot study of inhaled dry-powder mannitol during cystic fibrosis-related pulmonary exacerbation.
Pulmonary exacerbation treatment aims to eradicate increased respiratory symptoms and recover acute loss in lung function. Current treatment strategies remain suboptimal, with conventional intravenous antibiotics and intensive physiotherapy failing to achieve this in 25% of patients [1]. Despite this worrying statistic, optimising recovery from acute pulmonary exacerbations has not been a focus...
متن کاملInhaled dry powder mannitol in children with cystic fibrosis: A randomised efficacy and safety trial.
INTRODUCTION Inhaled mannitol has beneficial effects on lung function, mucociliary clearance, quality of life and sputum properties. This trial examined the efficacy of inhaled mannitol in children with cystic fibrosis (CF). METHODS The efficacy of inhaled mannitol in children with CF aged 6-17years was assessed in a phase 2, randomised, placebo-controlled crossover study. Subjects were rando...
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ژورنال
عنوان ژورنال: PULMONOLOGIYA
سال: 2017
ISSN: 2541-9617,0869-0189
DOI: 10.18093/0869-0189-2016-26-6-760-765